As the message is just a warning, you can disregard it.
I don't know much about clamav, but for virus scanners, what you want to keep up-to-date are the virus definitions.
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Martin Lee covers how Talos counters and defends at each step in the cyber kill chain model.
Set the Database Mirror in to be and then run freshclam update again.
[[email protected] ~]# /usr/bin/freshclam --datadir="/var/clamav" --log="/var/log/clamav/freshclam.log" --daemon-notify="/etc/clamd.conf" Clam AV update process started at Sun Aug 23 2009 is up to date (version: 51, sigs: 545035, f-level: 42, builder: sven) Trying host (1.218)...