TCAs are usually prescribed as a second-line treatment option prior to trying Monoamine Oxidase Inhibitors (MAOIs).
Below are several lists of TCAs grouped by how they function.
Ideal for depression sufferers with adult attention deficit disorder.
Pros: This noradrenergic/specific serotonergic (Na SSA, the newest class of antidepressants) also blocks receptors that cause sexual dysfunction in other antidepressants; less jitteriness and nausea.
Side effects: Nausea, insomnia, headaches, sexual dysfunction, jitteriness; possibly drowsiness, dry mouth, constipation.
It’s the worst one for weight gain, and among the worst for withdrawal symptoms (unless properly managed).
Whom it may be suitable for: Can be ideal for the elderly because of fewer side effects when prescribed at lower doses.
Pros: A very effective SSRI that can be easier to start and stay on than others.
Back when TCAs were approved, they were considered a first-line treatment option for depression.
These days they are still used for depression, but are considered a second-line treatment to newer drugs like SSRIs/SNRIs and atypical antidepressants.
Many still consider them to be highly effective, but newer medications are typically favored by professionals and patients because they carry less side effects and are regarded as being safer.
Pros: An SNRI that’s generally well tolerated if started in low doses.
Side effects: Can cause jitteriness, anxiety, insomnia; or can have the opposite effect (somnolence).