I just brought my two cats home from their dental cleaning and found out that they both have kidney disease. Both cats are active, eat well, drink water, and are not lethargic. I'm a senior citizen and cannot afford any more expense. And, it is extremely difficult for me to put them in their cat carriers. And, it bothers me that they are so very strssed out after their visit. Oh, I'm sorry to hear that you and your kitties are having these struggles.
They like to pay with my 18 mos grandson and like to play ball with me. The medication that I use the most often for sedation for travel is something called Acepromazine (also known as acevet or atravaet).
Be prepared when you get to the destination to quickly nip them into a room with tray and food/water, close the door and leave them quietly be. The reason you're apprehensive is mainly, I suspect, that all the journeys you've done with them have been pretty short and they've not had time on those trips to get over their squawky period and hunker down. PS - just to note that my cat carriers all have plastic bases so are impervious to pee coming through.is a well-known sedative for cats, according to Cat World.Catnip is a member of the mint family; in fact, if you crush the leaves, you will detect a faint scent of mint.They don't much like peeing en route and will tend to cross their legs - but if there's an accident you just whip a spare in to the carrier and put the wet one in a plastic bag.Then into the machine on a hot wash when you get to destination.