SNAIL (product of SNAI1) and SLUG are expressed in several types of human cancer, and their expression is often associated with low-histological grade of differentiation, tumour recurrence, metastasis and poor prognosis (Cobaleda et al, 2007; Wang et al, 2013).Although SNAIL and SLUG may induce the epithelial-mesenchymal transition, they have a role also in the maintenance of the stem cell-like properties of tumour cells.Approximately 90% of GISTs contain an activating mutation either in KIT or PDGFRA (platelet-derived growth factor receptor alpha) genes, which leads to ligand independent activation of these receptor tyrosine kinases (Hirota et al, 1998; Heinrich et al, 2003).
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