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Genital HSV-2 infection is more common in women (approximately one out of four women) than in men (almost one out of five).

This may be due to male-to-female transmissions being more likely than female-to-male transmission. HSV-1 and HSV-2 can be found in and released from the sores that the viruses cause, but they also are released between outbreaks from skin that does not appear to be broken or to have a sore.

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In addition, daily suppressive therapy for symptomatic herpes can reduce transmission to partners.

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