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Her performance qualifies her for heavy-duty roles." In late 2005, Mc Adams starred with Sarah Jessica Parker and Diane Keaton in the seasonal family comedy-drama The Family Stone, which gave Mc Adams an opportunity to play a dishevelled and sardonic sister, rather than the usual "obvious" girlfriend or wife roles.Vanity Fair invited Mc Adams, along with actresses Scarlett Johansson and Keira Knightley, to appear on its March 2006 cover, the annual Hollywood issue.The Italian-Canadian co-production was filmed in Sicily when Mc Adams was 22 years old, and it marked her first time on an airplane.Mc Adams' break-out role came in 2004, when she starred in the comedy film Mean Girls opposite Lindsay Lohan, Lacey Chabert, and Amanda Seyfried, based on Rosalind Wiseman's book Queen Bees and Wannabes.

Clearly the passion burned quite strongly between them too, because they even reunited briefly in the middle of 2008. After graduating from a four-year theatre program at York University in 2001, she worked in Canadian television and film productions such as the drama film Perfect Pie (2002), for which she received a Genie Award nomination, the comedy film My Name Is Tanino (2002), and the comedy series Slings and Arrows, for which she won a Gemini Award.In 2002, she made her Hollywood film debut in the comedy The Hot Chick.For the latter, she was nominated for the Academy Award for Best Supporting Actress.In 2016, she played Christine Palmer in the Marvel Cinematic Universe superhero film Doctor Strange.

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